Model question papers for m. Sc. Biochemistry programme



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MODEL QUESTION PAPERS

FOR

M.Sc.BIOCHEMISTRY PROGRAMME

(UNDER CSS)

AT

AFFILIATED COLLEGES OF

MAHATMA GANDHI UNIVERSITY

KOTTAYAM,KERALA

(W.E.F 2012-2013)

MAHATMA GANDHI UNIVERSITY

M.Sc. BIOCHEMISTRY PROGRAMME

BC1M001PC1 BIOCHEMISTRY

Time 3 hours Model question paper Total weight: 30

Part A

(Short answer questions- weight 1 each)

Answer any five of the following

1. Enumerate the functions of thromboxanes and prostaglandins

2. How does ATP serve as high energy compound?

3 Explain histone acetylation. What is its importance in DNA activation and inactivation?

4 Briefly explain the structure of ATP synthetase

5. Briefly describe gap junction proteins.

6. Describe the structure of oligosaccharide Antigens in human ABO blood group.

7. What are the functions of topoisomerases?

8. Describe the uses of exopolysaccharides from bacteria



Part B

(Short essay/ Problem solving type - weight 2 each)

Answer any five of the following

9. Describe the structure of t-RNA.what are its functions?

10 Explain the different types of lung surfactants and their role in prevention of pulmonary infection.

11. Briefly explain the functions of plant hormones

12 What are the structural characteristics of glycosaminoglycans?

13 Types of facilitated transport

14. Explain sodium –Potassium pump

15. What are fat soluble vitamins? Write a note on the structure and functions of any three of them.

16. Explain briefly the role of various antioxidants in biological systems.



Part C

( Long Essay Type- weight 5 each)

Answer any three of the following

17. Describe the mechanism of action of steroid hormones.

18.Explain the structure and function of hemoglobin.

19. What are repetitive DNA sequences? Outline their significance in molecular diagnosis.

20. Outline the major techniques used to study membrane structure.

21. Briefly explain the methods you will adopt for the purification and subsequent characterization of a heteropolysaccharide with a suitable example.

22. What are lipids? Describe in detail their classification



MAHATMA GANDHI UNIVERSITY

M.Sc. BIOCHEMISTRY PROGRAMME

BC1M001PC2 BIOPHYSICS, BIOINSTRUMENTATION AND BIOINFORMATICS

MODEL QUESTION PAPER

Time 3 hrs Total weight 30

Part A

Short answer questions; Answer any five questions. (Weight 1)

  1. Write short notes on confocal microscopy.

  2. Write notes on capillary electrophoresis.

  3. Write short notes on ultracentrifugation.

  4. Describe ion exchange chromatography.

  5. Explain flow cytometry.

  6. Write notes on refractometry.

  7. What is meant by sequence annotation?

  8. Briefly describe various methods of protein structure prediction

Part B

Short essay questions; Answer any five questions. (Weight 2)

  1. Write note on DNA protein interactions.

  2. Write notes on Ramachandran map

  3. Applications of uv visible spectroscopy



  1. Write notes on NMR spectroscopic method in the study of biomolecules

  2. Write briefly on the principles and applications of affinity chromatography.

  3. Write an account on Isoelectric focusing.

  4. Describe the tertiary and quarternary structure of hemoglobin.

  5. Write a note on phylogenetic trees.

Part C

Long essay questions; Answer any three questions. (Weight 5.)

17. Describe in detail SDS PAGE & AGE.

18. Explain in detail the principle and working of scanning and transmission electron microscopy.

19. Write an essay on the physics of LASER. Explain the different types of LASER and its application.

20. Write an essay on the 3 D structure of immunoglobulin.

21. Explain in detail the theory and working of HPTLC.

22. Write an essay on the scope and applications of Bioinformatics.

MAHATMA GANDHI UNIVERSITY

MSc BIOCHEMISTRY PROGRAMME

BCIMOO1PC3 PHYSIOLOGY AND BIOSTATISTICS

(MODEL QUESTION PAPER)

Time 3hrs Total weight 30

Section A

Short answer questions (weight 1 each)

I: Write notes on any five.


  1. Nephron

  2. Dyspnea

  3. Tidal volume

  4. Theories of xylem transport

  5. Mechanism of water transport across apoplasts in plants

  6. Proteolytic enzymes in the digestive process

  7. What is the significance of diffusion pressure deficit in water absorption?

  8. Mention the use of Chi square test

Section B

II: Write short essay on any five. (weight 2 each)



  1. Explain the role of partial pressure in ventilation.

  2. Write an account on action potential in cardiac muscle.

  3. Write on the physiological functions of liver.

  4. Explain the major theories of phloem transport in plants.

  5. How are minerals absorbed through roots? Explain.

  6. Write shortly on renal regulation of water.

  7. What are the physiological factors that affect dormancy, viability and germination of seeds?

  8. Explain the significance of correlations and variations in experimental research.

Section C

III. Answer any three in detail. (Weight 5 each)



  1. Describe the different types of muscles. Discuss the mechanism of muscle contraction.

  2. Write in detail the gas exchange and gas transport in human physiology.

  3. Explain the major physiological changes in plants towards physical and physiological drought situations.

  4. How do plants physiologically react towards salinity and heavy metal stress? Explain.

  5. Write an account on blood groups and blood transfusion in human system.

  6. Explain SPSS, its application in biology and the major advantages of it over Excel.


MAHATMA GANDHI UNIVERSITY

MSc Biochemistry Programme

BCIM 001PC4-CELL BIOLOGY AND GENETICS

MODEL QUESTION PAPER

Time 3hrs Total weight 30

Part A

I). Answer briefly any five of the following. (Weight 1 each)

1. Briefly explain the organization of eukaryotic chromosomes?

2. Briefly explain fluid mosaic model?

3. Briefly explain proton pumps

4. What is facilitated transport?

5. Briefly explain the different types of receptors?

6. What are the different cell cycle check points?

7. Briefly explain tumor suppressor genes and onco genes

8. Compare and contrast apoptosis and necrosis



(Weight 1×5=5)

Part B

II) Answer any five of the following (Weight 2 each)

9. Explain the different paths of apoptosis?

10. Explain the genetic control of embryonic development with a suitable model

Organism?

11. Explain Hardy –Weinberg principle? Explain the effect of deviation from Hardy –

Weinberg?

12. What are the different mechanisms of bacterial recombination?

13. What is cytoplasmic inheritance?

14. Briefly explain heritability and genetic advance?

15 What is linkage? Explain chromosome mapping with three point test crosses?

16. Briefly explain syndromes due to numerical aberrations in sex chromosomes?



(Weight 2×5=10)

Part C

III) Answer any three of the following in detail (Weight 5 each)

17. Explain in detail cell cycle regulation and check points?

18. Briefly explain developmental regulation in Drosophila?

19. What are the different classes of transposable elements?

20. a) A locus has three alleles, A1, A2, and A3 with frequencies 0.6, 0.3, and 0.1

respectively. Assuming random mating what is the expected frequency of all the
heterozygotes in the population?

b). The incidence of recessive albinism in 0.0004 in human population. What is the

frequencies of the recessive allele?

21. Briefly explain the genetic control of embryonic development in drosophila

22. Explain the theories of aging?

(Weight 5×3=15)

MAHATMA GANDHI UNIVERSITY

MSc BIOCHEMISTRY PROGRAMME

BC2M002PC5 –GENERAL MICROBIOLOGY


MODEL QUESTION PAPER

Time : 3 Hrs Total Weight: 30

Part A

I. Write Notes on Any Five (Wt: 1 each)

  1. Insertion sequences

  2. Enrichment media

  3. Fermentation

  4. Prions

  5. Lyophilization

  6. Photoreactivational repair

  7. Lowenstein – Jensen media

  8. Sterilization

Part B

II Write Short Essay on Any Five (Wt: 2 each)

  1. Conjugation

  2. Quorum sensing

  3. Transposons

  4. Phenol Coefficient Test

  5. Adansonian Classification

  6. Robertsonian Translocation

  7. Explain Flagellar Structure with a note on difference between prokaryotic & eukaryotic flagella.

  8. Viral Classification

Part C

III Answer Any Three in Detail (Wt: 5 each)

  1. Elaborate on the structure of bacterial cell wall with a note on peptidoglycan synthesis.

  2. Explain the mechanism of drug resistance in Bacteria

  3. Write in detail about aerobic respiration

  4. Elaborate on Generalized & Specialized transduction

  5. Classify fungi, with a note on economic importance of fungi.

  6. What are the Principles of Taxonomy? Describe in detail.


MAHATMA GANDHI UNIVERSITY

MSc BIOCHEMISTRY PROGRAMME

BC2M002PC6- Immunology


MODEL QUESTION PAPER

Time : 3 Hrs Total Weight: 30

Part A

I. Write Notes on Any Five (Wt: 1 each)

  1. Adjuvants

  2. Abzymes

  3. Immunofluorescence

  4. Chimeric antibody

  5. Superantigens

  6. Idiotype and Isotype

  7. Dendritic cells

  8. SCID Mice

Part B

II Write Short Essay on Any Five (Wt: 2 each)

  1. Active & Passive Immunization

10) Describe the process of Inflammation

11) Erythroblastosis foetalis

12) T- Cell Receptor Complex

13) MHC Molecules

14) ABO blood grouping

15) Mechanism involved in Graft Rejection

16) Mitogens

Part C

III Answer Any Three in Detail (Wt: 5 each)

17) Elaborate on the molecular basis of Antibody Diversity. Write a note on class switching.

18) Describe the various Antigen- Antibody reactions in detail.

19) Describe the different types of Hypersensitivity reactions.

20) What is autoimmunity? Describe the various autoimmune diseases.

21) What are Complements? How are they involved in the defense mechanism?

22) Explain the process of B – cell maturation, activation & differentiation.

MAHATMA GANDHI UNIVERSITY

MSc BIOCHEMISTRY PROGRAMME

BC2M 002 PC7 CORE COURSE 7

MOLECULAR BIOLOGY AND GENETIC ENGINEERING

MODEL QUESTION PAPER

Time 3hrs Total weight 30

Part A

I). Answer briefly any five of the following. Weight 1 each

1. What are okazaki fragment?

2. What are different modes of replication?

3. What are different types of transcription termination mechanisms?

4. Explain monocistronic and polycistronic mRNA?

5. Explain post translational import?

6. Briefly explain molecular mechanism of ribozymes?

7. What are thermo stable DNA polymerases?

8. Compare and contrast E coli DNA ligase and T4 DNA ligase?



(Weight 1×5=5)

Part B

II) Answer any five of the following (Weight 2 each)

9. What are repetitive DNA sequences?

10. Briefly explain an experiment to prove semi conservative mode of replication?

11. Briefly explain different steps in prokaryotic and eukaryotic transcription?

12. What is mRNA splicing?

13. Briefly explain hormonal regulation of gene expression?

14. Briefly explain difference of prokaryotic and eukaryotic transcription?

15 Briefly explain the importance of Cohen and Boyer patents?

16. What is pharming? Explain with suitable examples?



(Weight 2×5=10)

Part C

III) Answer any three of the following in detail (Weight 5 each)

17. Explain the enzymology of DNA replication?

18. Explain post transcriptional modification of eukaryotic mRNA?

19. Explain protein tableting?

20. Explain chemical synthesis of DNA

21. Explain Sangers DNA sequence?

22. Explain applications of molecular biology in forensic medicine, Archeology and


Paleontology

(Weight 5×3=15)

MAHATMA GANDHI UNIVERSITY

M Sc BIOCHEMISTRY PROGRAMME

ENZYMOLOGY

BC3MOO3PC9 Core Course 9

Model Question Paper
Time: 3 hrs Total credits: 30

Part A

Short answer questions; Answer any five of the following Weight: 1 each



  1. What is the significance of active site in enzymatic reactions?

  2. What are the disadvantages of using Line-Weaver Burk plot?

  3. Distinguish between lyases and ligases.

  4. What are immobilized enzymes?

  5. What do you know about induced fit hypothesis?

  6. Define Katal and International Unit.

  7. What are suicidal Inhibiitors? Give examples

  8. What do you know about enzyme therapy?

Part B

Short essay/Problem solving type. Answer any five of the following Weight: 2 each



  1. Derive Michaelis Menten equation.

  2. Describe the reaction mechanisms of bisubstrate reaction.

  3. Distinguish between non-competitive and uncompetitive inhibition with the help of Line-weaver Burk plot.

  4. Outline the industrial application of enzymes.

  5. What is the role of coenzymes in enzymatic catalysis?

  6. Write a note on Enzyme specificity

  7. Explain regulation of metabolic pathways by covalent modification of enzymes.

  8. How do you determine the type of inhibitors graphically?

Part C

Long essay type. Answer any three of the following Weight: 5 each



  1. Explain the mechanism of action of serine proteases.

  2. Describe the kinetics of allosteric enzymes.

  3. Give an idea about the isolation methods for enzymes.

  4. What are the different factors that affect velocity of enzyme catalyzed reactions?

  5. Explain the role of multienzyme complexes in the regulation of metabolic pathways.

  6. Describe the clinical and therapeutic importance of enzymes.


MAHATMA GANDHI UNIVERSITY

M Sc BIOCHEMISTRY PROGRAMME
BC2MOO2PC8 METABOLISM AND BIOENERGETICS
MODEL QUESTION PAPER
Time: 3 hrs Total weight: 30

Part A

Short answer questions; Answer any five of the following Weight: 1 each



  1. What is the importance of phosphorylated intermediates in metabolism?

  2. What do you mean by substrate level phosphorylation? Give examples.

  3. Write a note on the importance of glyoxylate pathway.

  4. Describe the importance of Nernst equation.

  5. Why HDL is known as good cholesterol and LDL is known as bad cholesterol?

  6. Explain the importance of Cori cycle.

  7. What is the clinical significance of ketone bodies?

  8. What is the importance of metagenomics?

Part B

Short essay/Problem solving type. Answer any five of the following Weight: 2 each



  1. Discuss the importance and regulation of Urea cycle.

  2. Explain the degradation of saturated and unsaturated fatty acids.

  3. Discuss the regulation of pyrimidine degradation.

  4. What do you know about shuttle systems? Give examples.

  5. Explain how fructose and galactoses are metabolized in our body?

  6. Describe chemiosmotic hypothesis? How uncouplers work?

  7. Distinguish between transamination and oxidative deamination.

  8. Explain the degradation of heme.

Part C

Long essay type. Answer any three of the following. Weight: 5 each



  1. Explain the biodegradation of aromatic amino acids. Give an idea about the inborn errors associated with it.

  2. Describe in detail the fate of pyruvate formed in glycolysis during aerobic and anaerobic conditions

  3. Discuss about the electron carrier complexes in electron transport chain.

  4. Explain the various reactions in Kreb’s Cycle.

  5. Discuss Cholesterol Biosynthesis and its regulation.

  6. Describe the role of protein kinases in signal transduction with the help of a suitable example.


MAHATMA GANDHI UNIVERSITY

M Sc BIOCHEMISTRY PROGRAMME
BC3MOO3PC9 ENZYMOLOGY
MODEL QUESTION PAPER
Time: 3 hrs Total weight: 30

Part A

Short answer questions; Answer any five of the following Weight: 1 each



  1. What is the significance of active site in enzymatic reactions?

  2. What are the disadvantages of using Line-Weaver Burk plot?

  3. Distinguish between lyases and ligases.

  4. What are immobilized enzymes?

  5. What do you know about induced fit hypothesis?

  6. Define Katal and International Unit.

  7. What are suicidal Inhibiitors? Give examples

  8. What do you know about enzyme therapy?

Part B

Short essay/Problem solving type. Answer any five of the following Weight: 2 each



  1. Derive Michaelis Menten equation.

  2. Describe the reaction mechanisms of bisubstrate reaction.

  3. Distinguish between non-competitive and uncompetitive inhibition with the help of Line-weaver Burk plot.

  4. Outline the industrial application of enzymes.

  5. What is the role of coenzymes in enzymatic catalysis?

  6. Write a note on Enzyme specificity

  7. Explain regulation of metabolic pathways by covalent modification of enzymes.

  8. How do you determine the type of inhibitors graphically?

Part C

Long essay type. Answer any three of the following Weight: 5 each



  1. Explain the mechanism of action of serine proteases.

  2. Describe the kinetics of allosteric enzymes.

  3. Give an idea about the isolation methods for enzymes.

  4. What are the different factors that affect velocity of enzyme catalyzed reactions?

  5. Explain the role of multienzyme complexes in the regulation of metabolic pathways.

  6. Describe the clinical and therapeutic importance of enzymes.


MAHATMA GANDHI UNIVERSITY

M. Sc BIOCHEMISTRY PROGRAMME
BC3MOO3PC10 PLANT BIOCHEMISTRY
MODEL QUESTION PAPER

Time:3 hours Total weight: 30


Part A

Short answer questions; Answer any five of the following Weight: 1 each

  1. Write the reaction catalysed by Ribulose biphosphate carboxylase. Mention its importance in photosynthesis.

  2. Describe the term ‘CAM’.

  3. Distinguish between auxins and gibberellins.

  4. What is the importance of nif genes?

  5. What are the major functions of alkaloids?

  6. What do you mean by photosynthetic efficiency?

  7. What is the importance of Jasmonic acid in plant defence?

  8. Point out the importance of glyoxysomes and peroxysomes.

Part B

Short essay/Problem solving type. Answer any five of the following Weight: 2 each

  1. Give an account on the structural details of chloroplast.

  2. Explain the mechanism of action of abscissic acid.

  3. Distinguish between cyclic and non-cyclic photosynthetic pathways.

  4. What are the major functions of alkaloids?

  5. List out the enzymes important in nitrate metabolism

  6. Detail the significance of photorespiration.

  7. What is the importance of phenolic compounds?

  8. Describe the importance and application of synthetic hormones.

Part C

Long essay type. Answer any three of the following Weight: 5 each

  1. Describe the ways in which secondary metabolites are useful for humans.

  2. Explain the biosynthesis of terpenoids

  3. Detail the chemical reactions involved in the dark phase of photosynthesis.

  4. Classify alkaloids and discuss their important role in plants.

  5. Explain the mechanism of action of nitrogenase enzyme.

  6. Discuss the biosynthesis of cytokinins.


MAHATMA GANDHI UNIVERSITY

M. Sc BIOCHEMISTRY PROGRAMME
BC3MOO3PC11 MOLECULAR ENDOCRINOLOGY

MODEL QUESTION PAPER

Time 3 hrs Total weight 30

Part A

Short Answers (Write any 5 out of 8) Weight 1each

  1. What are neurohormones?

  2. Write down the functions of adrenal gland.

  3. Write a note on hyperglycemia.

  4. How are thyroid hormones transported?

  5. What is diabetes insipidus?

  6. Name the hormone whose second messenger is cGMP and indicate how cGMP is formed.

  7. What are goitrogenic compounds?

  8. What are the structural differences between proinsulin and insulin?


Part B

Short Essay (Write any 5 out of 8) Weight: 2 each

  1. Write a note on non-steroid hormones.

  2. What is thyroglobulin? Describe the role of thyroglobulin in the biosynthesis of thyroid hormones

  3. Describe the major molecular events involved in the uptake and metabolism of iodine by thyroid cells.

  4. What are the major biochemical effects of insulin?

  5. Write a note on endocrine disorders.

  6. Describe the hormonal control of calcium homeostasis.

  7. Describe the endocrine role of kidney.

  8. Describe the function of pituitary gland.


Part C

Long Essay (Write any 3out of 6) Weight: 5each

  1. Describe the current concepts of the molecular mechanism of action of insulin.

  2. Write briefly on:-

(a) Insulin secretion (b) Adrenergic receptors (c) PTH

  1. Describe the classification, synthesis, circulation and metabolism of steroid hormones.

  2. Write an essay on the different molecular mediators of hormone action.

  3. Explain the different techniques used in cellular and molecular endocrinology

  4. Describe reproductive hormones and explain the endocrinology of pregnancy.


MAHATMA GANDHI UNIVERSITY

M. Sc BIOCHEMISTRY PROGRAMME
BC3MOO3PC12 NEUROBIOLOGY

MODEL QUESTION PAPER

Time 3hrs Total weight 30



Part- A

Answer any five (weight-1)

1. Briefly describe the structure of neuron with diagram


2. Define synaptic cleft, synaptic delay, threshold stimulus and refractory period
3. Mention the name and role of protein involved in the docking of neurotransmitter vesicles.

4. What is resting potential?


5. Discuss the classification of neuron on the basis of their morphology, function and by the
neurotransmitter released.
6. Describe voltage clamping
7. Short notes on: (a) Declaratine memory and procedural memory
(b) Short –term memory and long-term memory
(c) Non-associative and associative memory
8. Give an account on the neurotransmitter derived from tryptophan and its function in neurotransmission

Part B

Answer any five (weight-2)
9. Give detailed description of synaptic structure and synaptic plasticity
10. Explain in detail voltage dependent sodium channel and voltage depended potassium channel
11. Describe about patch-clamp technique
12. What is meant by chemical synapse transmission and electrical synapse transmission?
13. Neuropathology of Alzheimer’s disease
14. What is a neuromuscular junction? Explain excitation-contraction coupling
15. Describe the steps between the time an impulse reaches the terminal knob of a pre-synaptic neuron
and an action potential is initiated in a post –synaptic cell.
16. Discuss the chemistry, synthesis, storage, release, mechanism of action and inactivation of
acetylcholine
Part C

Answer any three (weight-5)
17. What is an action potential? What are the steps leads to its various phases?
18. Outline the symptoms, etiology, neuropathology, and treatment of Parkinson’s disease.
19. Give an account on the structure and function of blood-brain barriers
20. Describe the organization of central nervous system and peripheral nervous system.
21. Explain in detail the biosynthesis, mechanism of action and functions GABA and NO.
22. Give the details of Na-K pump.


MAHATMA GANDHI UNIVERSITY

M. Sc BIOCHEMISTRY PROGRAMME
BC4MOO4 PE1 CLINICAL BIOCHEMISTRY
MODEL QUESTION PAPER
Part A

Answer any five (weight 1)

1. Write a note on (a) Pre-analytical variables

(b) Analytical variables

(c) Post-analytical variables in quality control

2. What you mean by osmolarity of water and free water clearance

3. Write about the stimulation test used in the gastric function tests

4. Describe insulin tolerance test

5. Write about AIDS and its clinical diagnosis

6. Explain DNA probes

7. Explain any one disorder of erythrocyte metabolism

8. What is Glycated Hemoglobin? How it is used in the diagnosis of Diabetes Mellitus

Part B

Answer any five (weight-2)

9. Write briefly on the method of collection, storage and processing of blood specimen for
biochemical analysis?

10. Describe Restriction Fragment Length Polymorphism

11. Write an account on the use of radioactive isotopes in diagnosing diseases.

12. Examination of amniotic fluid

13. Write down the deficient enzymes, symptoms, clinical diagnosis and treatment of
aminoacidurias

14. Describe Niemaan Pick disease

15. Explain polymerase chain reaction and write down the use of PCR

16. Describe the prenatal diagnosis of inborn errors of metabolism

Part C

Answer any three (weight-5)

17. Mention the disorders of carbohydrate metabolism and explain

18. Describe quality control in a clinical laboratory

19. Renal function tests

20. Mention and explain the disorders associated with nucleic acid metabolism

21. Explain the neonatal screening for hypothyroidism and phenylketonuria

22. Which are the tests to be done to find out the proper functioning of liver? Describe in detail.


MAHATMA GANDHI UNIVERSITY

M. Sc BIOCHEMISTRY PROGRAMME

BC4MOO4 PE2-Elective

ENVIRONMENTAL SCIENCES

MODEL QUESTION PAPER

Time -3 hrs Total Credits -30



Part A

(Short Answer Questions; Weight -1 each)

Answer any five of the following


  1. Mention the crucial atmospheric factors that determine the climate of a place. Explain

  2. Explain the major environment factor that determines the balance of the hydrosphere

  3. What do you mean by the structure of an ecosystem?

  4. Explain cybernetics of an ecosystem

  5. Why is dissolved oxygen highly significant to aquatic systems?

  6. Distinguish between BOD and COD

  7. Distinguish between α- diversity and ϒ-diversity

  8. What is the basic criterion to declare a species endangered? 1 X 5 =5

Part B

(Short Essay/ Problem Solving type; Weight -2 each)

Answer any five of the following


  1. Mention the major water quality parameters and their standard limits as per any national or international norms

  2. What are primary air pollutants? Explain the major environment impact of primary air pollutants in automobile exhausts

  3. Explain radiation fallout. Mention the sources and the major environment impacts of radiation fallout

  4. What are the major soil physical properties? Mention the significance of soil structure in fertility

  5. Why is tertiary treatment of water difficult to achieve and remains costly? Explain

  6. What are xenobiotics? Explain the major environment impacts of xenobiotics

  7. Explain how significant biofertilizers to sustainable agriculture? Give examples of biofertilizers mentioning their mode of action

  8. Explain CITES. How significant is this international treaty in conservation of species?

2 X 5 = 10

Part C

(Long Essay type – Weight 5 each)



Answer any three of the following

  1. Explain the various applications of microbes in environment cleaning. Mention the constraints and priorities of bioremediation

  2. Explain Phytoremediation. Mention the different kinds of phytoremediations and the applications of each kind.

  3. Compare and contrast Activated Sludge Process and Trickling Filter Treatment of waste water

  4. Explain the major kinds and sources of terratogens and carcinogens in the environment and mention the methods of assessment of toxicity and environment risk of such agents

  5. Compare and comment on the significance of Stockholm conference and Rio conference on the emerging of global environment policies

  6. Explain the details of the 1992 National Environment Policy of India. Mention how this policy document reflects constitutional provisions of environment protection in the country?

MAHATMA GANDHI UNIVERSITY

M. Sc BIOCHEMISTRY PROGRAMME
BC4MOO4PE3- NUTRITION HEALTH AND LIFE STYLE DISEASES

MODEL QUESTION PAPER

Part A

Answer any 5 weight 1


  1. Define BMR. How is it determined?

  2. Write notes on any four deficiency diseases associated with vitamin- A.

  3. Explain the special care to be taken during pregnancy with regard to the diet.

  4. Write notes on the nutritional requirement during peptic ulcer.

  5. Comment on the nutritional requirement during infantile biliary cirrhosis.

  6. Define respiratory quotient. What are the factors affecting it?

  7. Write notes on Type II nephritis and the nutritional requirement during this period.

  8. Explain the terms

  1. Protein Efficiency ratio

  2. Specific Dynamic Action


Part B

Answer any 5 weight 2


  1. Explain in detail the digestion and absorption of carbohydrates.

  2. Explain in detail Protein Calorie Malnutrition.

  3. Explain atherosclerosis. Enumerate the possible etiological factors for the same.

  4. Write notes on the food requirements during infancy.

  5. Write notes on cirrhosis of liver. Describe the dietetic management and food requirement during this period.

  6. Comment on geriatric nutrition.

  7. Comment on the physiological role of Calcium, Magnesium and Iron.

  8. Describe the sources, daily requirement and deficiency diseases associated with

vitamin D.
Part C

Answer any 3 weight 5


  1. Comment on dietetic management on the following

  1. Jaundice and viral hepatitis

  2. Gastritis

  1. Define water soluble vitamins. Discuss the daily human requirement, sources and deficiency states of any four of them.

  2. Describe the digestion and absorption of proteins

  3. Explain in detail the inter relationship between nutrients.

  4. Explain in detail the nutritional requirement during cancer and comment on the role of food in the prevention of cancer.

  5. Comment on the nutritional and food requirement for an expectant mother.


MAHATMA GANDHI UNIVERSITY

M.Sc. BIOCHEMISTRY PROGRAMME

BC4M004 PE4 Research methodology, IPR and Bioethics

MODEL QUESTION PAPER

Time 3 hours Total weight 30

Part A

(Short answer questions- weight 1 each)

Answer any five of the following

Write briefly on

1. Trade Secret

2. Advantages and disadvantages of PBR

3. Library resources

4. Hypothesis

5. Plagiarism

6. Ecological impact of GM crops

7. Discussion in research publication

8 Ethical aspects of embryonic stem cells for therapy



Part B

(Short essay/ Problem solving type - weight 2 each)

Answer any five of the following

9 Explain sampling error

10. Briefly explain sampling design

11. Discuss the regulations for use of animals in research

12. Explain patent databases

13 What are the various types of diagrammatic representation of data?

14. Explain patent infringement with an example.

15. Importance of search engines in information retrieval.

16 Give an account of ethical and safety aspects of animal cloning.

Part C

(Long Essay Type- weight 5 each)

Answer any three of the following

17. Describe the major aspects of a good research design.

18. Explain the major elements of a scientific paper.

19. Define data. Mention the different kinds of data, their levels of measurement and the various methods of data collection.

20. Explain library classification. Mention its significance.

21. Briefly explain the different types of patents. What is the procedure involved in filing for a patent application

22. Discuss the ethical and safety issues involved in testing of drugs on human volunteer.


MAHATMA GANDHI UNIVERSITY

M.Sc. BIOCHEMISTRY PROGRAMME

BC4M004PE4 PLANT AND ANIMAL CELL CULTURE
MODEL QUESTION PAPER
Time 3 hours Total weight 30

Part A

(Short answer questions- weight 1 each)

Answer any five of the following



  1. Techniques used for cell separation

  2. Describe the various changes undergone by the cells during cryopreservation

  3. Differentiate between primary and secondary cell culture

  4. Construct a vector map of a plant transformation vector indicating all the key features

  5. How does Bt toxin confer pest resistance in plants.What are its disadvantages?

  6. What are the various applications of tissue engineering?

  7. Advantages of immobilized cell culture

  8. Explain rotary bioreactor.

Part B

(Short essay/ Problem solving type - weight 2 each)

Answer any five of the following

9. Differentiate between serum containing and serum free media

10. Outline the steps involved in the initiation of callus culture

11. Describe the possible measures to be taken on observing fungal/bacterial contamination in your cell culture plates.

12. Differentiate between Ti and Ri plasmids.

13. Describe the mechanism of siRNA mediated gene silencing.

14. Outline the various methods available for invitro testing of drugs

15. Transfer of antibiotic resistance genes is one of the issues raised in association with GM crop.What alternatives can be used to overcome this problem?

16. Describe the Principle of tissue engineering



Part C

( Long Essay Type- weight 5 each)

Answer any three of the following

17. Describe the requirements for successfully conducting animal cell culture

18. what are the various gene transfer techniques used in plant cell culture

19. Describe somatic hybridisation and selection.

20.Therapeutic applications of cell culture technology

21. Describe the requirements for maintenance of cell lines. Explain the properties of cell in culture.

22. Explain in detail the classification, culture of stem cells. What are its important applications?



MAHATMA GANDHI UNIVERSITY

M.Sc. BIOCHEMISTRY PROGRAMME

BIOCHEMICAL TOXICOLOGY

MODEL QUESTION PAPER
MODEL QUESTION PAPER

Time: 3 hours Total weight 30
Part A

(Short answers- weightage 1)


  1. What are the biomarkers of toxicity?

  2. How is the toxicity testing done and what are the test protocols?

  3. What do you mean by genetic toxicity testing and mutagenesis assay?

  4. What is fluctuation test?

  5. What is direct toxic action?

  6. Describe immunotoxicity.

  7. What are the biochemical markers of cardiac damage?

  8. What is teratogenesis?


Part B

(Short essay- weightage 2)



  1. What are the factors affecting toxic responses?

  2. What are the measurements of dose- response mechanism?

  3. Describe briefly Ames test.

  4. What are host-mediated assay and dominant lethal tests?

  5. What do you mean by tissue specific toxicity?

  6. What are the responses during cellular toxicity?

  7. What are the pharmacological effects of toxicity?

  8. Describe what multi-organ toxicity is.

Part C

(Long essay- weightage 5)


  1. Describe the biochemical mechanisms of toxicity.

  2. Describe the different types of metabolic changes occurring during toxicity and the various mechanisms of detoxifications.

  3. What are chemical carcinogens? How do they act in our body?

  4. Describe the interaction of toxic compounds with specific protein receptors.

  5. What is neurotoxicity? What are neurotoxic agents? Describe mechanism of action of nuerotoxicity with two examples?

  6. What are the biomarker criteria of toxicity and describe the new technologies used for the evaluation of toxicity interaction.


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