Timed Free Response Essay Mutations
1. Certain human genetic conditions, such as sickle cell anemia, result from single base-pair mutations in DNA.
(a) Explain how a single base-pair mutant in DNA can alter the structure and, in some cases, the function of a protein.
(b) Explain, using a specific example, the potential consequences of the production of a mutant protein to the structure and function of the cells of an organism.
(c) Describe how the frequency of an allele coding for a mutant protein may increase in a population over time.
Total /7=____
General Rubric
Criteria A
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Supporting Details A (1pt)
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Supporting Details A (1pt)
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Supporting Details A (1pt)
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Total=3
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Explain how a single base-pair mutant in DNA can alter the structure and, in some cases, the function of a protein
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a.) Explanation of what single base-pair mutations are
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b.)Explanation of how a single base-pair mutation can affect the structure of a protein.
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c.) Describe an example of a base-pair mutation.
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Criteria B (2pts)
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Supporting Details B (1pt)
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Supporting Details B (1pt)
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Total=2
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Explain, using a specific example, the potential consequences of the production of a mutant protein to the structure and function of the cells of an organism.
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d.) Provide a specific example of consequences of the production of a mutant protein
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e.) Explain why or how a mutation can affect the function of the cells of an organism
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Criteria C (2pts)
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Supporting Details B (1pt)
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Supporting Details B (1pt)
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Total=2
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(c) Describe how the frequency of an allele coding for a mutant protein may increase in a population over time.
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f) Provide an explanation of how the frequency of an allele coding for a mutant protein may increase in a population over time.
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g) Explain a hypothetical or real example of mutant protein increasing in a population over time.
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