Exact Sciences Master Guide2005/2006



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Molecular Medicine

  1. Department of Pharmacochemistry


General introduction

During the Master's of Molecular Medicine students can specialise themselves by doing a Major in one of the following disciplins:



  • Drug Discovery & Target Finding (Molecular Pharmacology)

  • Drug Disposition & Safety (Molecular Toxicology)

  • Biomolecular & Drug Analysis

 

The research training  in the three specialisations takes place in the following sections:

Section Medicinal Chemistry (prof. dr. R Leurs)


  • Drug Discovery & Target Finding (Molecular Pharmacology)

Section Molecular Toxicology (prof. dr. N.Vermeulen):

  • Drug Disposition and Safety (Molecular Toxicology)

Section Analytical Chemistry and Applied Spectroscopy (prof. dr. H. Irth):

  • Biomolecular & Drug Analysis

 

Students are urged to contact the mastercoordinator of Molecular Medicine as soon as possible with their choice of research group. Research training (Major) will be wound up with a Master thesis and an oral presentation. Research training (Minor) ends with a written report.

 

Master programme Molecular Medicine



An overview of the available courses is given below.

 


  • Compulsory courses

Principles of  Molecular Medicine

Molecular pharmacology and toxicology of drugs

Bioanalytical Aspects of drug discovery I

 


  • Introductory course specialisation

Pharmacodynamics of drug action

Drug toxicity: concepts and experimental approaches

 


Receptor structure and function

Drug Disposition and Safety Assessment

Bio-Analytical Aspects of Drug Discovery II

 


  • Optional courses

Drug Registration and Safety Assessment

In vitro Pharmacology / Toxicology and High-Throughput Screening

(Pharmaco / Toxico) Genomics and -proteomics

 

Courses LACDR (Leiden - Amsterdam Centre of Drug Research)



Courses MNS

Courses Chemistry


      1. Current research themes


Drug Discovery & Target Finding (Molecular Pharmacology)

(dr. M.J. Smit, room O2.26, phone: +31 (0) 20 59 87579, dr. R.A. Bakker, prof. dr. R. Leurs)

To gain experience in formulating a scientific question, setting up and carrying out molecular pharmacological experiments, to answer that question, interpreting data obtained, designing further experiments and reporting both orally and in writing.

The student will participate in one of the research projects within the research programme 'Structure-function relationships of biological active compounds: G protein coupled receptors and their ligands'. The membrane-bound G protein coupled receptors play a key role in cellular (patho) physiology and are currently one of the most favored drug targets.

Research focuses on the histaminergic receptors, with emphasise on the recently cloned H3 (multiple isoforms) and H4 (new potential target inflammation) receptors and recently initiated new line on human and viral-encoded chemokine receptors. Interest is directed at the ligand-receptor interaction and signaling pathways activated by these receptors.

Research  topics comprise intriguing pharmacological concepts such as constitutive activity and dimerization of receptors and their role in the process of drug discovery.

Besides classical pharmacological, molecular biological approaches, cell culture techniques and modern techniques (reportergene, fluorescent techniques) are applied to obtain more insight in the receptors. Research is performed in close collaboration with the synthetical and computational groups in order to ensure a multidisciplinary approach.

 

Drug Disposition & Safety Assessment (Molecular Toxicology)

(dr. J.N.M. Commandeur, room P2.56, phone: +31 (0) 20 59 87595, prof. dr. N.P.E. Vermeulen,)

Training in and gaining experience in defining a scientific research question, designing and carrying out molecular toxicological experiments to answer that question, validating and interpreting of the experimental data, evaluating and discussing the results and the perspectives, and reporting both orally and in writing.

The research performed in the division of Molecular Toxicology, is focussed on the role of biotransformation enzymes in the bioactivation and detoxification of xenobiotics, and the characterisation of the structure and properties of the metabolites formed.

In the research training, students can participate in one of the research projects carried out at this division. Subjects of the research projects include: expression of wild-type and mutant cytochrome P450s (P450s) and characterisation of their structural and catalytic properties; investigation of dynamics of P450s using various (laser)spectroscopical methods (RAMAN, FRET, NMR); development and use of wild-type and mutant P450s as bioreactors to produce bioactive compounds; development of automated high-resolution bioaffinity screening and detection systems using cytochrome P450s and estrogen receptors as detector proteins; development and evalution of selenium-containing compounds as chemoprotective compounds; role of biotransformation in estrogenic properties of xenobiotica.

Research is performed in close cooperation with the computational group.

 

Biomolecular & Drug Analysis

(prof. dr. H. Irth, dr. H. Lingeman, room M3.30, phone: +31 (0) 20 59 87539)

To obtain knowledge and experience in the field of biomolecular and drug analysis, getting acquainted with various analytical approaches to study protein-ligand interactions, drug-matrix interactions, development of quantitative bio-analytical and pharmaceutical methods and reporting both orally and in writing.



The main goals is to improve the selectivity and sensitivity / analyte detectability of total analytical systems. With large series of samples such as frequently encountered in real-life screening (e.g. biological samples) or monitoring studies, speed of analysis is another aspect of current interest. The emphasis, therefore, is on the development of on-line and, preferably, fully automated systems. This implies that much attention is devoted to the design and optimization of multidimensional methods. In this context important developments are in coupled-column systems, in combination with on-line bio-specific reaction and mass-spectrometric detection.  The emphasis will be on systems that can be used for drug-protein interactions, determination of metabolic products, enzymes, proteins, nucleotides, receptors, etc.


Course code

Course name

Cr.

Period

430063

Principles of Molecular Medicine

6

1

435597

Bio-Analytical Aspects of Drug Discovery I

6

1 and 3

435674

Molecular Pharmacology and Toxicology of Drugs

6

2

435686

Pharmacodynamics of Drug Action

3

4

435682

Drug Toxicity: Basic Concepts and Experimental Approaches

3

4

435598

Bio-Analytical Aspects of Drug Discovery II

6

4, 5 and 6

435681

Advanced Course on Drug Disposition & Safety Assessment (Molecular Toxicology)

6

4, 5 and 6

435680

Receptor Structure and Function

6

4, 5 and 6

470707

Ethics

3

23.01.2006 - 03.02.2006



    1. Communication variant (C-variant)

      1. General


This variant is intended for students with a BSc degree in any of the beta-studies who want to specialize in communication. The programme focuses on science communication theory and research as well as on science communication in practice. This includes science journalism as well as museology, the use of internet for science communication and health communication.

 

The variant is coordinated by prof. dr. Jaap Willems. Adress: Faculty of Earth and Life Sciences, Dept. of Science Communication, De Boelelaan 1087, room B0.29, e-mail jaap.willems@falw.vu.nl.



 

Teaching in this variant is mainly in Dutch.


      1. Programme


For a specialization degree it is required to spend 60 cp on Science Communication items. Three courses, one internship or research project and a thesis are compulsory. The rest of the programme can be filled in with optional courses. In research projects students will focus on an aspect of science communication, while in internships students will work on a project at a trainee post in a museum, editorial office of a newspaper etc. There they will also do a small research project. The thesis consists of a study of literature on an aspect of science communication.


C-variant compulsory courses

Also a individual Internship/research project (21 sp) and a individual Thesis (9 sp)

Course code

Course name

Cr.

Period

471014

Wetenschapsjournalistiek

6

03.10.05 - 28.10.05

471006

Communicatiewetenschappen

6

05.09.2005 - 30.09.2005

471032

WTC onderzoek

6

31.10.05 - 25.11.05




C-variant optional courses




Course code

Course name

Cr.

Period

991000

Interpersoonlijke communicatie

3

28-11-2005/09-12-2005

471026

Museologie en buitenschoolse educatie

6

09.01.2006 - 03.02.2006

470562

Interactive Communication

3

12.12.05-23.12.05

470087

Gezondheidscommunicatie

6

13.03.2006 - 07.04.2006

471033

Wetenschapscommunicatie via internet

6

28.11.05 - 23.12.05



    1. Education variant (E-variant)


The teaching in these variant is mainly in Dutch. Therefore we also give the requirements in Dutch.
      1. Programma


De opleiding voor het behalen van de eerstegraads lesbevoegdheid start twee keer per jaar, in september en in februari. De opleiding wordt aangeboden in twee semesters. Uitgaande van de start in september duurt semester 1 tot en met januari en semester 2 tot juli. De opleiding is sterk praktijkgericht. De helft van de opleiding bestaat uit praktijk door werkervaring of stage (ook wel schoolpracticum genoemd) op een school voor voortgezet onderwijs. Daarnaast kent de opleiding vier componenten: vakdidactiek, algemene didactiek/pedagogiek, praktijkonderzoek en keuzemodulen. Studenten die bij de Communicatie variant de vakken 'interpersoonlijke communicatie' en 'museologie en buitenschoolse educatie' volgen, krijgen bij de lerarenopleiding een vrijstelling voor keuzemodulen, een deel van het praktijkonderzoek en een deel van algemene didactiek.
      1. Toelatingseisen


Er worden twee cursussen ter oriëntatie aangeboden: 'Oriëntatie op Communicatie en Educatie 1' en 'Oriëntatie op Educatie 2' (vakcodes 990005 en 990007). Beide cursussen zijn te volgen als keuzevakken tijdens de bacheloropleiding.

 

Wie deze vakken niet heeft gevolgd, dient een afspraak te maken de betreffende vakdidacticus. In een intakegesprek wordt dan beoordeeld of er toch direct met de lerarenopleiding gestart kan worden.


      1. Keuzemodulen


Het Onderwijscentrum VU biedt keuzemodulen aan. Eén van de mogelijkheden is één of meer van de door het instituut aangeboden keuzemodulen te volgen. De docent in opleiding kan er echter ook voor kiezen om een bepaald aspect van een schoolvak of een aspect van het leerproces van leerlingen of van het coachen van leerlingen nader te bestuderen. In overleg met de begeleider stelt de docent in opleiding dan zelf de inhoud van deze keuzemodule valt.

 

Door het Onderwijscentrum VU worden onder andere de volgende keuzemodulen aangeboden:



  • Docent in Europa

  • Oriëntatie lesgeven in het hbo

  • Oriëntatie lesgeven in het vmbo

  • Excursie naar Gent, Duitsland of Florida

  • Petje af

  • Mores leren

  • Digitale video-analyse

 

Binnen de clusters en vakken worden keuzemodulen aangeboden als: Veldwerkweek, Klassieke Culturele Vorming (KCV), Culturele en Kunstzinnige Vorming (CKV) en Taalleerproblemen.

Elk keuzemodule heeft een omvang van 2 sp. Het onderwijs wordt gegeven in het voorjaar 2006 als werkcollege op maandag. Toetsing geschiedt door middel van een opdracht. De literatuur wordt bij aanvang van de cursus bekend gemaakt.

Deze keuzemodulen zijn alleen te volgen als onderdeel van de universitaire lerarenopleiding.



 

Opmerkingen



In het voorjaar worden het definitieve aanbod van keuzemodulen bekend gemaakt. De inschrijving voor de modulen vindt dan plaats.
      1. Meer informatie


De lerarenopleiding wordt verzorgd door het Onderwijscentrum VU. Bij het Onderwijssecretariaat kan meer informatie worden gevraagd, tel.: (020) 59 89222, e-mail: onderwijssecretariaat@ond.vu.nl.


Educatie variant (scheikunde)

Tevens 4 sp aan keuzemodulen

Vakcode

Vaknaam

Stp.

Periode

990002

Praktijk

30

Het vak beslaat 2 semesters, en loopt daarbij parallel aan de vakdidactiek en de algemene didactiek / pedagogiek. Zo is ook een goede wisselwerking mogelijk tussen theorie (colleges) en praktijk.

990122

Vakdidactiek scheikunde

9

Het vak beslaat 2 semesters (een heel studiejaar). Startmomenten zijn aan het begin van de semesters: in september en in februari.

990003

Praktijkonderzoek

8

Het praktijkonderzoek vindt plaats in de tweede helft van de lerarenopleiding.

990001

Algemene didactiek / pedagogiek

9

Het vak beslaat 2 semesters (een heel studiejaar). Startmomenten zijn aan het begin van de semesters: in september en in februari.



    1. Society oriented variant (M-variant)

      1. General


Due to the growing complexity of technological and medical issues and the interaction with society, organisations working in this sector have a growing and urgent need for academic professionals in the natural and life sciences, who have knowledge of policy management and entrepreneurship. The M-variant offers students with a bachelor degree in the natural and life sciences the chance to combine a specialization in this field with a specialization in research, communication or education.
      1. Programme


The programme of the M-variant is equal to the first year of the master programme Management Policy- Analysis and entrepreneurship (MPA) (for a detailed description of the programme see the description of the master programme MPA). The programme of the M-variant consists of 60 cp (15 cp compulsory courses; 15 cp optional courses and 30 cp internship)  The course language is English, unless all students participating in the course speak Dutch, the course language will be Dutch. The program coordinator is: dr. M.B.M. Zweekhorst. Address: Faculty of Earth and Life Sciences, department Biology and Society, De Boelelaan 1087, room A0.62, phone: +31 (0) 20 59 87033, e-mail marjolein.zweekhorst@falw.vu.nl


Course code

Course name

Cr.

Period

470707

Ethics

3

23.01.2006 - 03.02.2006




M-variant compulsory courses




Course code

Course name

Cr.

Period

470572

Communication, Organization and Management

6

03.10.05-28.10.05

470571

Analysis of Governmental Policy

6

05.09.05 ¿ 30.09.05

470573

Business Management in Health and Life Sciences

3

31.10.05 ¿ 11.11.05




M-variant optional courses

Recommended courses



Course code

Course name

Cr.

Period

991000

Interpersoonlijke communicatie

3

28-11-2005/09-12-2005

470576

Policy Research Project

6

09.01.2006 ¿ 03.02.2006

470562

Interactive Communication

3

12.12.05-23.12.05

470574

Clinical Development and Clinical Trials

3

14.11.05 - 25.11.05

470578

Interactive Health Technology Assessment

3

14.11.05 - 25.11.05

470575

Entrepreneurship in Health and Life sciences

6

28.11.05-23.12.05

470564

Caput Criteria for Corporate Social Responsibility

3

31.10.05 - 11.11.05

470581

Caput Success Factors in Sustainable Innovations

3

In consultation





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