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Research on the neonatal consequences of prenatal exposure to buprenorphine is quite limited. Research on the neonatal consequences of prenatal exposure to buprenorphine is quite limited. Not enough births have been followed for a sufficient period of time to collect convincing data regarding factors such as cognitive and social development. Same issue of confounding parental and family factors in teasing apart developmental effect. Reviews in Jones et al., Drugs, 2012, and Addiction, 2012 MOTHER: Sites Johns Hopkins U PI: H. Jones Lead Site Brown U PI: B. Lester Thomas Jefferson U PI: K. Kaltenbach U Vermont PI: S. Heil U Vienna PI: G. Fischer U Toronto PI: P. Selby Vanderbilt U PI: P. Martin Wayne State U PI: S. Stine PI: A. Arria Coordinating Center Compared with methadone-exposed neonates, buprenorphine-exposed neonates Required 89% less morphine to treat NAS Spent 43% less time in the hospital Spent 58% less time in the hospital being medicated for NAS Both medications in the context of comprehensive care produced similar maternal treatment and delivery outcomes Significant results are encircled. Site was a blocking factor in all analyses. The O’Brien-Fleming α spending function resulted in α = .0091 for the inferential tests of the Medication Condition effect for the 5 primary outcome measures at the conclusion of the trial. Notes: Jones et al., N Engl J Med. 2010 Clinically meaningful attrition rate in buprenorphine condition Low rates of illicit drug use during pregnancy and at delivery Maternal outcomes similar in the 2 study conditions Bonferroni’s principle was used to set familywise α = .003125 (nominal α = .05/16) for the secondary outcome measures. Note: Jones et al., N Engl J Med. 2010
Relationship between Methadone Dose and 9 Clinical Neonatal Outcomes ( N=73) Total amount of morphine for NAS (mg) Duration of treatment for NAS (days) Duration of neonatal hospital stay (days) Gestational age at delivery (weeks) Neonatal head circumference (cm) Methadone and Buprenorphine: NAS Jones et al., Neurotoxicol Teratol, 2013
Relationship between Buprenorphine Dose and 9 Clinical Neonatal Outcomes ( N=58) Total amount of morphine for NAS (mg) Duration of treatment for NAS (days) Duration of neonatal hospital stay (days) Gestational age at delivery (weeks) Neonatal head circumference (cm) Methadone and Buprenorphine: NAS
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