Name: Peter Richards Brink

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Name: Peter Richards Brink
Present Position:

Professor and Chairman

Department of Physiology and Biophysics

School of Medicine

Health Sciences Center

State University of New York at Stony Brook

Long Island, NY 11794

Parsons College, Fairfield, Iowa Biology

B.A. Quinnipiac University, Hamden, CT 1969 Biology

M.S. Southern Connecticut State University 1971 Biology

Ph.D. University of Illinois, Urbana 1976 Physiology

Teaching Assistant, Southern Connecticut State Univ., 1969-1971

Teaching Assistant, University of Illinois, 1971-1972

USPH Trainee, University of Illinois, 1972-1975

Post-doctoral fellow, S.U.N.Y. at Stony Brook, 9/75-8/77

Lecturer, Anat. Science, S.U.N.Y. at Stony Brook, 9/77-8/78

Research Assistant Professor, Department of Anat. Sci., S.U.N.Y. at Stony Brook, 8/78-1/80

Assistant Professor, Department of Anat. Sci., S.U.N.Y. at Stony Brook, 1/80-12/85

Associate Professor, Department of Anat. Sci., S.U.N.Y. at Stony Brook,1/86-8/90.

Professor, Department of Anat. Sci., S.U.N.Y. at Stony Brook 8/1/90-8/15/90.

Professor, Department of Physiology and Biophysics, SUNY at Stony Brook, 8/15/90-8/1/97

Professor and Chairman, Department of Physiology and Biophysics, SUNY at Stony Brook 8/1/97-present


Joint Appointment (Associate Professor), Department of Physiology and Biophysics 8/86- 8/90.

Joint Appointment (Professor), Department of Anat. Sci., S.U.N.Y. at Stony Brook, 8/15/90 - present

Member of the Institute of Molecular Cardiology, SUNY Stony Brook: directed by Dr. Ira Cohen,


Adjunct Professor of Urology, Albert Einstein College of Medicine. 8/4/03-present

Society Memberships:

Biophysical Society

American Physiological Society

Reviewer for:

Journal of Cell Biology, Biophysical Journal, American Journal of Physiology, Science, Nature Journal of Neurobiology, Journal of Membrane Biology, Journal of Physiology, Journal of General

Physiology, Pflugers Arch, International J. Physiology and Biophysics, Circulation Research, Journal of Vascular Biology

Member of the editorial board for Cell Communication and Adhersion. Editor-in-chief: Bruce Nicholson
National Institutes of Health:

Member, Cellular Biology and Physiology Study Section, 10/86-10/90

Ad Hoc Reviewer for Cell Biology Study Section, 1985, 1995

Ad Hoc Reviewer: Heart/Lung P.P.G. Program

Special Study Section/CBY chair 1994/1995/1996/1997

Ad Hoc Reviewer for ESTA 2004

Ad Hoc Reviewer for BSCT 2004

Member, MBPP Study Section 2005

International Human Frontiers Science Program, Strausberg, France, Reviewer

Chairman for the Workshop on Gap Junctions: their role in tissues at the IUPS in St. Petersberg 1997

Fellowships and Honors:

NIH Postdoctoral Fellowship Award, 9/75 - 8/77

USPH Trainee Fellowship (Training Grant U. of Ill. Physiology) 6/72- 8/75

Award of recognition for outstanding teaching in the Medical School, awarded by the class of 1990

Recipient of the President's award for excellence in teaching, 1993

Recipient of the Chancellor's award for excellence in teaching, 1993

Research Grant History:

NIH - GM- 24905 "Coupled and uncoupled junctional membranes." ($143,051) 1/1/79-12/31/81 (P.I.)

NIH- AG 18750 "Contractile mechanisms of invertebrate striated muscles." ($136,951) 7/1/81 - 6/30/84 (Co-I)

NIH General Research Support Grant - "Single channel conductance of the nexus and the effects of deuterium oxide." ($3,000) 4/1/82-3/31/83 (P.I.)

NIH Equipment Support Grant - Shared TEM, STEM, and X-ray Microscope ($200,000,1983) (Co-I)

NIH - GM 24905 "Intercellular communication." ($195,000) 7/1/83-6/31/86 (P.I.)

NSF - "Junctional membrane channel regulation." ($55,000) 6/1/84-12/1/86 (P.I.)

Johnson & Johnson - "Biophysics of Skin." ($20,000) 11/5/86-11/4/87. (P.I.)

NIH - HL 31299 "A model for the intercalated disc." ($145,000) 3/1/85-8/30/88 (P.I.)

NIH - GM 24905 "Intercellular communication." ($234,000) 7/1/86-6/31/90 (P.I.)

NIH - HL 31299 "A model for the intercalated disc." ($352,087) 3/1/89 -2/28/94 (P.I.)

NIH - AG 10199 "Age-Related Changes in Bone Cell Signal Transduction" 10/1/91-5/1/94 (15,000/year) Co-I.

EPRI - Electromagnetic field effects on osteoblasts (300,000) 9/1/91-6/1/95 (Co-I, 15,000/year)

Support for Dr. M. Khan/ Educational Commission for Foreign Medical Graduates/fellowship (30,000) 9/1/94-8/31/95

NIH - EY 09406 "Neuromodulation of Secretion from Lacrimal Plasma Cells," (600,000) (P.I.) 1/1/92-05/1/96

NIH – EY 09406 "Neuromodulation of Secretion from Lacrimal Plasma Cells," (700,000) (Co-I) 7/1/96-7/2/99

NIH - DK 46379 Gap junctions and ion channels in human corpra cavernosum. (sub- contract- 17,000/year) 4/1/95-3/31/99

NIH - HL 31299 Cx43 and Cx37 gap junction channel gating. (P.I., 450,000) 7/1/95-6/30/99

NIH - GM 55263 Permselectivity Properties of connexins (P.I., 1, 000,000) 4/1/97-7/31/02

NIH - HL 59199 Heteromeric Connexons and Cardiovascular Function. sub-contract -(50,000/ year) 9/1/98-8/30/02

United States Department of Education (Graduate Assistant in Areas of National Need. GAANN). Co-PI (100,000/year) 1/30/2000-2/1/2003.

US Army USAMRMC 013356029 (Y.X. Oin, P.I.). Stress Fracture Etiology is Dependent on Mechanically Induced Fluid Flow. 3/1/02-3/2/04 186,532/year (15,000 to P. Brink)

NIH - DCO5491-01 (White) Connexins and deafness 4/1/02-4/2/04 (Co-I, 25,000/year)
Present Grant Support:

NIH - GM 55263 Gap junction permselectivity: A mutagenic approach. (P.I., 1,100,000) 8/1/02-7/31/06

NIH - NIDDK (PPG) at Albert Einstein College of Medicine, P.I- A Melman, project 3# (Brink-P.I.) Second messengers and the role gap junctions in smooth muscle of the bladder and corpora. 4/1/03-4/2/08 150,000/year

NIH - EY014604 Water Transport in the Lacrimal Gland 4/15/03-4/16/07 (P.I.1,200,000)

NIH HL-070161 Ischemic Preconditioning (PR Brink, Co-I) 4/15/03-3/31/07 225,000/year direct costs

NIH - HL 59199 Heteromeric Connexons and Cardiovascular Function. sub-contract -(80,000/ year) 81/04-7/30/08

Guidant, Mesenchymal stem cells, a cellular delivery system for pacing the heart, I Cohen P.I. (8/31/04-7/21/09) Project 3 (P. Brink, P.I.) 320,000/year. Core facility (P. Brinkk, P.I.) 290,000/year.

Teaching Experience:

HBY 531 Organ Systems Physiology and Structure for Medical and Dental Students (Course Director: 1990-1993; 1995-1996).

BIO 328 Mammalian Physiology. Lectures on male and female reproductive systems and gastrointestinal physiology 1995-1998

HBA 530 Human Microscopic Anatomy for Medical and Dental Students (Course Director 1986-1990), Taught all laboratories from 1979-1990. Lectured on tissues, gastrointestinal, and skin

HBY 531 Human Physiology for Medical and Dental Students (lectures on GI Function, 1986-present; lectures on skin structure and function, 1993-1996).

HBA 470/472 Human Microscopic Anatomy for Allied Health Students.(1983, 1986-1993)

BCD/BMO 656 Cell Biology (Graduate Course) 1978-1991.

BCD/BMO 657 Developmental Biology (Graduate Course) 1980-1991.

HBA 410 Neuroscience (1978 - 1986)

HBA 300 Human Biology (1977-1978, 1982)

Member of the following graduate programs on campus: Physiology and Biophysics, Biophysics, Anatomical Sciences and Neurobiology and Behavior.

Doctoral Students:

Vytautas Verselis, Ph.D 1985 (January) - Position: Professor, Department of Neuroscience, Albert Einstein School of Medicine.

Roger Cameron, Ph.D 1990 (August) - Position: Research Assistant Professor, Department of Physiology and Biophysics, SUNY at Stony Brook.

Bonnie Bunch, M.D. 1990 (May) - Ph.D 1994 (December) Present Position: Assistant Professor, Department of Pediatrics, Director of the Child Neurology, University of South Dakota.

Undergraduate students: Howard Hughs Medical Institute Summer Scholars:

Kerry Cronin, 1994-96 MD. from NYU in 2000

Alycia Thomas 1997-1998 premed/ accepted to SUNY Stony Brook in 1998, M.D. 2002
External Examiner for:

Michael Blennerhasset, Western Ontario University, Canada

William Cole, McMaster University, Canada

Andre Goland, N.Y.U.

Dolores Beblo, Syracuse HSC

Musa, Hassan. Syracuse HSC

Thesis Committees served on while at Stony Brook:

Joseph Margiotta (Anatomy,1980) Deborah Kuterback (BCD,1985)

Maryann Rapuano (BCD,1986) Anthony Ross (Anatomy,1987)

Roger Sauterer (BCD,1988) Robert Fenney (BCD,1989)

Arthur Cohen (BCD,1991) Jiann-Liang Chen (Physiology, 1993)

Chris Kushmerick(Physiology, 1996) James Tonra(Biophysics,1996)

Monique Vander Molen(Physiology, 1997) Chris Picken, (2002)

Lori Seischab, (Physiology, 2002) Fransico Martinez (Physiology, 2002)

Zaher Nahle (Physiology, 2003) Marvin O’Neal (Physiology, 2004)
Post-doctoral Fellows:

S. V. Ramanan, post-doc 3/87 - 10/91. Fellow Physics Institute, Madras, India from 10/91-10/92.

From 4/93 to the present, Assistant Professor of Physiology and Biophysics SUNY at Stony Brook.

Present position; Director of research (biophysics) Madras Institute of Technology and Science.

Stewart W. Jaslove, 1/84 - 9/87. Research Fellow Neuroscience Institute, New York from 9/87-1/94. Presently Dr. Jaslove is working for a pharmaceutical firm.

Kathrin Banach, 5/1/96- 12/5/97 - Ph.D Physiology, University of Berne, Switerland 1995

Present position: Assistant Professor, Department of Physiology, Loyola University Ill.

Seminar Director, Anatomical Sciences, 9/81 - 12/83

Executive Committee, School of Medicine, 11/81 - 5/89

Faculty Senate, School of Medicine, 9/81 - 8/90

Executive Committee, Cellular and Developmental Graduate Biology, 9/80 - 7/83, 9/85-6/90

Graduate Admissions Committee, Department of Anatomical Sciences, 9/82-8/90.

Curriculum Committee, School of Medicine, 9/83 - 4/98

Teaching Evaluation/Awards Committee (Medical School Only) 8/91-8/93

Curriculum Subcommittee for years 1 and 2, chairman 92-97

Task Force on accreditation, 1992

Ad Hoc committee for Pathology Review, 1993

Ad Hoc committee for review of medical student admissions 1993

Ad Hoc committee on indirect cost returns 1993

University Teaching Awards Committee 1994

Senate's Council on Faculty Rights and Responsibilities 1997-present

Provost's Research Advisory Group (RAG) 1999-2001

Search Committee for Dean of the Medical School, October 2002-2004

Division of Laboratory Animal Resources: advisory committee, chair November 2002- present

Research Goals and Interests:

The research effort in my laboratory focuses on intercellular communication mediated by gap junctions and mechanisms of solute/water secretion in lacrimal acinar cells.

Intercellular Communication: Gap Junctions

The laboratory has an ongoing interest in connexins of cardiac myocytes and vascular smooth muscle cells. They are essential to processes such as vaso-motor tone and cardiac arrhythmias. Much of our effort focuses on quantification of gap junction selectivity to solutes of the size and charge of metabolites and second messengers. Our most recent data shows that mesenchymal stem cells are able to form gap junctions with cardiac myocytes. These data show that mesenchymal stem cells can be used as a cellular delivery system for a variety of molecules. The stem cell research project is done in collaboration with Dr Ira Cohen at Stony Brook and Drs Richard Robinson and Micheal Rosen at Columbia University.

In a related project we are designing paradigms to test whether stem cells can be used to trigger PKC activity via the transfer of specific solutes from stem cell to smooth muscle cells or cardiac myocytes.

This is a consequence of a collaboration with Dr. George Christ where the focus is on the role of cell to cell communication in diabetes. Data from Hela cells and vascular smooth muscle cells suggests that PKC is able to effect a selective alteration of Cx43 selectivity which is altered in the STZ rat model for diabetes.

Lacrimal gland secretions

The lacrimal gland is a major source of fluid to the surface of the eye. The transport of solutes across the epithelium of the lacrimal gland generates tear fluid and is therefore potentially a major site in causing dry eye for example. We use knockout mice devoid of specific transporters and/or channels to understand the molecular basis of fluid secretion. We have developed an in situ method to measure stimulated and non-stimulated tear flow from the lacrimal gland. We also use perforated and whole cell patch clamp along with monitoring of cell volume regulation to assess the processes responsible for secretion at the cellular level. This work is done in collaboration with Dr. Leon Moore, Dr. Gary Matthews and Dr Ben Walcott.

Publications in refereed journals:

1) 1973 Dierolf, B. M. and P. R. Brink. Effects of thermal acclimation on cable constants of the earthworm median giant axon. Comp. Biochem. Physiol. 44A:401-406.

2) 1977 Brink, P. R. and L. Barr. The resistance of the septum of the median giant axon of the earthworm. J. Gen. Physiol. 69:517-536.
3) 1977 Kensler, R. W., P. R. Brink and M. M. Dewey. Demonstration of an A-type nexus between glial cells in the earthworm ventral nerve cord. Amer. J. Anat. 149:605-611.
4) 1977 Kensler, R.W., P.R. Brink and M.M Dewey. The nexus of the frog ventricle. J. Cell Biol. 73:768-781.
5) 1978 Brink, P. R. and M. M. Dewey. Nexal membrane permeability to anions. J. Gen. Physiol. 72:67-86.
6) 1979 Brink, P. R., R. W. Kensler and M. M. Dewey. The effect of lanthanum on the nexus of the anterior byssus retractor muscles of Mytilus edulis L. Amer. J. Anat 154:11-26
7) 1979 Brann, L., M. M. Dewey, E. A. Baldwin, P. R. Brink and B. Walcott. Requirements for in vitro shortening and lengthening of isolated thick filaments of Limulus striated muscle. Nature 279:256-257.
8) 1979 Kensler, R. W., P.R. Brink and M.M Dewey. The septum of the lateral axon of the earthworm: a thin section and freeze fracture study. J. Neurocytology 8:565-590.
9) 1980 Brink, P. R. and M. M. Dewey. Evidence for fixed charge in the nexus. Nature 285:101-102.
10) 1981 Brink, P.R., M.M. Dewey, D. Colflesh and R. W. Kensler. Polymorphic nexuses in the earthworm Lumbricus terrestris. J. Ultra Res. 77:233 240.
11) 1983 Brink, P. R. The effect of deuterium oxide on junctional membrane channel permeability. J. Memb. Biol. 71:79-87.
12) 1983 Kubota, K., B. Chu, S. Fan, M. M. Dewey, P. R. Brink and D. Colflesh. Quasi-elastic light scattering of suspensions of Limulus thick myofilaments in relaxed, activated and re-relaxed states. J. Mol. Biol. 166:329-340.
13) 1984 Verselis, V. and P. R. Brink. I-V characteristics of the septa of earthworm giant axon under voltage clamp. Biophysical J. 45:145-147.
14) 1984 Brink, P. R., V. Verselis and L. Barr. Solute-solvent interac-tion in junctional membranes. Biophysical J. 45:121-124.
15) 1984 Brink, P. R. and V. Verselis. Effect of elevated hydrogen and deuterium ion on junctional membrane permeability. N.Y.A.S. First Colloq. in Biological Science 435:523-526.
16) 1984 Williamson, D. L., P. R. Brink and G. Zieve. Spiroplasma fibrils. International Congress of the International Organization for Mycoplasmalogy. J. Med. Sci. 20:830-835.
17) 1985 Brink, P. R. and S. V. Ramanan. A diffusion model for the septate axon: Junctional permeability and cytoplasmic diffusion coefficients. Biophysical J. 48:299-309.
18) 1986 Jaslove, S. W. and P. R. Brink. The Mechanism of Rectification at the Electrotonic Motor Giant Synapse of the Crayfish. Nature 323:63-65.
19) 1986 Verselis, V. and P. R. Brink. The Gap Junction Channel: It's hydrophilic nature, as indicated by deuterium oxide effects. Biophysical J. 50:1003-1007.
20) 1987 Garber, M. L., P. R. Brink, D. Dilillio, P. Devine and E. Pastoriza-Munoz. Permeabilizing the granular cell of toad and turtle bladder: lack of cell coupling. Am. J. Physiol. 253:F588-F594.
21) 1988 Brink, P. R., R. T. Mathias, S. W. Jaslove, and G. J. Baldo. Steady-state current flow through gap junctions: Effects on intracellular ion concentrations and fluid movement. Biophys. J. 53:795-808.
22) 1989 Cohen, A. J., D. W. Williamson and P. R. Brink. A Motility of Spiroplasma melliferum Induced with Nitrous Acid. Current Microbiology 18:219-222.
23) 1989 Brink, P. R. and S. F. Fan. Patch clamp studies from membranes which contain gap junction channels. Biophys. J. 56:579-593.
24) 1990 Walcott, B.W. and P.R. Brink. Innervation of the plasma cell compartment in a lacrimal gland. N.Y.A.S. 594:425-428

25) 1990 Ramanan, S. V., and P.R. Brink. Alternate Methods of Representing Single-Channel Data. Biophys. J. 57:893-901.

26) 1990 Ramanan, S. V., and P.R. Brink. Exact solution of a Model of diffusion in an infinite chain or monolayer of cells coupled by gap junctions. Biophys. J. 58:631-640.
27) 1990 Pasquale. L.R., R.T. Mathias, L. Austin, P.R. Brink, and M. Cinunga. The Electrostatic Properties of Fiber Cell Membranes from the Frog Lens. Biophys. J. 58:939-945.
28) 1990 Brink, P.R., E. Roemer, and B. Walcott. Maxi-K Channels in Plasma Cells. Plugers Arch. 417:349-351.
29) 1991 Brink, P.R., Gap junction channels and cell-to-cell messengers in myocardium J.Cardiovascular Electrophysiology. 2:360-366.
30) 1992 Manivannan,K, S.V. Ramanan, R.T. Mathias and P.R. Brink. Multichannel recordings from membranes which contain gap junctions Biophys. J. 61:216-227.
31) 1992 Ramanan, S.V., S.F. Fan and P.R. Brink. Model invariant method for extracting single-channel mean open and closed times from heterogeneous multichannel records. J. Neuro. Met. 42:91-103
32) 1993 Rup, D.M., R.D. Veenstra, H. Wang, P.R. Brink, and E.C. Beyer. Chick Connexin56, a lens gap junction protein. J. Biol. Chem. 268:706-71
33) 1993 Christ, G., P.R. Brink, W. Xhaop, J. Moss, C.M. Gondre, C. Roy, and D.C. Spray. Gap junctions modulate agonist efficacy during activation of the alpha1 adrenergic receptor by phenylephrine and oxymethazoline in isolated rat aorta. J. P.E.T 266:1054-1065
34) 1993 Ramanan, S.V. and P.R. Brink. Multichannel recordings from membranes which contain gap junctions. II. Substates and conductance shifts. Biophys. J. 65:1387-1395
35) 1993 Chirst, G., D.C. Spray and P.R. Brink. Characterization of K currents in cultured human corporal smooth muscle cells. J. Andro.14:319-328
36) 1993 Christ, G., P.R.Brink, A. Melman and D.C. Spray. The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human cavernosum smooth muscle. I.J.I.R. 5:77-96
37) 1993 Andersen, J., E. Grine, C.Eng, K. Zhao, R.L. Barbieri, J.C. Chumas and P.R. Brink. Expression of Connexin43 in Human myometrium and Leiomyoma. Am. J. Ob/Gyn 169:1266-1276.
38) 1994 Brink. P.R., B. Walcott, E. Roemer, E. Grine, M. Pastor, G. Christ and R. Cameron. Modulation of Immunoglbulin secretion by avian plasma cells. J. of Neuroimmunology 51: 113-121
39) 1994 Ramanan, S.V., V. Mesimeris and P.R. Brink. Ion flow in the bath and flux interactions between channels. Biophys. J. 66:989-995
40) 1994 Veenstra, R.D., Z. Wang, E.C. Beyer, S.V. Ramanan and P.R. Brink. Connexin37 forms high conductance gap junction channels withg subconductance state activity and selective dye and ionic permeabilities. Biophys. J. 66: 1915-1928
41) 1994 Veenstra, R.D., Z. Wang, E.C. Beyer and P.R. Brink. Selective dye and ionic permeability of gap junction channels form by connein45 Channels. Cir. Res.268: 706-712
42) 1994 Christ, G., P.R. Brink and S.V. Ramanan. Dynamic gap junctional communication: a delimiting model for tissue responses Biophys. J. 67:1335-1344.
43) 1994 Chirst, G., M. El-Sabban, L. Moore, D.S. Spray and P.R. Brink . A Contracao dos vasos Sanguineos Ciencia Hoje 18:80-86. (Science News) Brazil
44) 1994 Brink, P.R., B. Walcott, E. Roemer, R. Cameron and M. Pastor. The role of membrane channels in IgG secretion in plasma cells in the lacrimal gland of chicken. In: The Lacrimal Gland, Tear Film and Dry Eye Syndromes AEMB 350: 151-156

45) 1994 Walcott, B., R. Cameron and P.R. Brink. The anatomy and innervation of lacrimal glands. In: The Lacrimal Gland, Tear Film and Dry Eye Syndromes AEMB 350:11-18

46) 1994 Cameron, R., B. Walcott, S.F. Fan, M. Pastor, E. Grine and P.R. Brink Second messenger modulation of IgG secretion from chicken lacrimal gland. In: The Lacrimal Gland, Tear Film and Dry EyeSyndromes AEMB 350: 133-139
47) 1994 Walcott, B., R. Cameron, E. Grine, E. Roemer, M. Pastor and P.R. Brink Anti-muscarinic acetylcholine receptor-like immunoreactivity in lacrimal glands. In: The Lacrimal Gland, Tear Film and Dry Eye Syndromes AEMB 350:61-65
48) 1995 Fan, S.F., P.R. Brink, A. Melman and G. Christ. An analysis of the maxi-K channel in cultured human corpral smooth muscle cells. J. Urol. 153:818-825.
49) 1995 Donahue, H.J., K.J. McLeod, C.T. Rubin, J Andersen, E. Grine, E.L. Hertzberg and P.R. Brink. Cell to cell communication in osteoblastic networks cell line-dependent hormonal regulation of gap junction function J. Bone Min. Res. 10: 881-889.
50) 1995 Donahue, H.J., F. Guilak, M. A. Vander Molen, K. J. McLeod, C.T. Rubin, D.A.Grande and P.R. Brink. Chondrocytes Isolated from mature articular cartilage retain the capacity to form functional gap junctions. J. Bone Min. Res. 10:1359-1364.
51) 1995 Cameron, R., B. Walcott, N. Claros, K. Mendel and P.R. Brink. Cholinergic modulation of immunoglobulin from avain plasma cells: the role of cyclic nucleotides. J. of NeuroImmunology. 61:223-230.
52) 1995 Veenstra, R.D., H.Z. Wang, D.A. Beblo, M.G. Cliton, A.L. Harris, E.C. Beyer and P.R. Brink. Selectivty of connexin specific gap junction does not correlate with channel conductance. Cir. Res. 77:1156-1165
53) 1996 Brink, P.R., S.V. Ramaman and G.J. Christ. Human connexin43 gap junction channel gating: evidence for mode shifts and/or heterogeneity. Amer. J. Physiol. 271:C321-C331.
54) 1996 Brink, P.R., K Cronin, and S.V. Ramanan. Gap junctions in excitable cells J. BioEnergtics and BioMembranes.28:351-358.
55) 1996 Christ, G.J., D.C. Spray, M. El-Sabban, L. Moore and P.R. Brink. Gap junctions in vascular tissues: evaluating the role of intercellular communication to the modulation of vasomotor tone. Cir. Res. 79: 631-646
56) 1996 Schirrmacher, K., D. Nonhoff, M. Wiemann, E. Peterson, P. R. Brink, D. Bingmann. Effects of calcium on gap junctions between osteoblast-like cells in culture. Calcif. Tissue Int. 59:259-264
57) 1996 Brink, P.R. Gap junction channel gating and permselectivity:their roles in coordinated tissue function.Clincal and Exper. Pharm. and Physiol. 23:1041-1046
58) 1996 Veenstra, R.D., and P.R. Brink. Do Connexin channels have a residual state? Biophys. J. 70:1082-1084.
59) 1997 Rehman, J., Chenven, E., Brink, P.R., Grine, B., Walcott, B., Melman, A., and Christ, G.J.: Diminished neurogenic-, but not pharmacologic-induced intracavernous pressure responses in the 3 month Streptozotocin (STZ)-diabetic rat. Am. J. Physiol. 272:H1960-H1971.
60) 1997 Schirrmacher, K., S.V. Ramanan, K. Cronin, D. Bingmann, E. Petersen and P.R. Brink. Voltage sensitivity of gap junction channels in rat osteoblast-like cells. BBA 1327:89-96
61) 1997 Brink, P.R., K. Cronin, K. Banach, E. Peterson, E.M. Westphale, K.H. Seul, S.V. Ramanan, and E.C. Beyer Evidence for heteromeric gap junction channels composed of hCx37 and rCx43. Amer. J. Physiol. 273 C1386-C1396.
62) 1998 Brink,P.R., E. Peterson, K. Banach and B. Walcott. . Electrophysiological Evidence for reduced water flow from lacrimal gland acinar epithelium of NZB/NFW F1 mice. AEMB 438:209-219
63) 1998 Walcott, B., N. Claros, A. Patel and P.R. Brink. Age-related decrease in innervation density of the lacrimal gland in mouse models of Sjorgren's syndrome. AEMB 438:917-923
64) 1998 Ramanan, S.V., P.R. Brink and G. Christ. Neuronal innervation, intracellular signal transduction and intercellular coupling: A model for syncytial tissue responses.. J. Theor. Biol. 193:69-84
65) 1998 Brink, P.R. Gap Junctions in vascular smooth muscle. Acta. Scand. Physiol. 164: 349-356
66) 1999 Goldfine, S.M., B. Walcott, P.R. Brink, N. Magid, and J.S. Borer Myocardial connexin43 expression in left ventricular hypertrophy resulting from aortic regurgitation. CardioVascular Path. 8:1-9
67) 1999 Fan,. F.S, G.J. Christ, A. Melman and P.R. Brink. A stretch-sensitive Cl- channel in human croporus cavernosal myocytes. I. J. I.R. 11:1-7.
68) 1999 Lee, S.W, H-Z Wang, W. Zhao, P. Ney, P.R. Brink and G.J. Christ. Prostaglandin E1 activates the large-conductance Kca channel in human corporal smooth muscle cells. I.J.I.R. 11:189-199
69) 1999 Christ, M. Spektor, P. R. Brink, L. Barr. Further evidence for the selective disruption of intercellular communication by heptanol Am. J. Physiol. 276: 1911-1917
70) 1999 Christ, G.J. and P.R. Brink An analysis of the presence and physiological relevance of subconducting states of connexin43-derived gap junction channels in cultured human corporal vascular smooth muscle cells. Cir. Res. 84::797-803
71) 1999 Ramanan, S.V., P.R. Brink, K. Varadaraj, E. Peterson, K.Schirrmacher and K. Banach. A three-state model for Connexin37 gating kinetics. Biophys. J. 76:2520-2529
72) 2000 Brink, P.R., J. Ricotta, and G.J. Christ Biophysical characterization of gap junctions in vascular wall cells: implications for vascular biology and disease. Braz. J of Med. and Biol. Reseach. 33:391-398
73) 2000 Beyer, E.C., J Gemal, K.H. Seul, D.M. Larson, K. Banach, and P.R. Brink Modulation of intercellular communication and heteromeric mixing of co-expressed connexin. Braz. J of Med. and Biol. Reseach. 33:415-422
74) 2000 Christ G.J., and P.R. Brink Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication. Braz. J of Med. and Biol. Research. 33:423-430
75) 2000 Banach, K., S.V. Ramanan, and P.R. Brink The influence of surface charge on the conductance of the human connexin37 gap junction channel. Biophys. J. 78: 752-760.
76) 2000 Valiunas, V. R. Weingart and P.R. Brink Formation of heterotypic gap junction channels by connexins Cx40 and Cx43. Cir Res. 86:e42-e49
77) 2000 Brink, P.R., Commentary: Gap junction voltage dependence: A clear picture emerges J. Gen Physiol. 116:11-12.
78) 2000 Kurmari, S., K. Varadaraj, V. Valiunas, S. V. Ramanan, E.A. Chrisensen, E.C. Beyer, and P.R. Brink Functional expression and biophysical properties of polymorphic variants of the human gap junction protein Cx37. BBRC 274:216-224.

79) 2001 Kumari, S., K. Varadaraj, V. Valiunas and P.R. Brink. Site-directed mutations in the transmembrane domain M3 of human connexin37 alter channel conductance and gating. BBRC. 280:440-447

80) 2001 Berthoud, v., De.A. Montegna, N. Paranjothi, N. Aithal, P.R. Brink, and E.C. Beyer. Heteromeric connexons formed by lens connexins, Cx43 and Cx56. E. J.C.B. 80: 11-19
81) 2001 Wang, H.Z., N. Day, M. Valcic, K.Hsieh, S. Serels, P.R. Brink and G.J. Christ. Intercellular

communication in cultured human vascular smooth muscle cells. Amer. J. Physiol. 281:75-88

82) 2001 Valiunas, V., J. Gemel, P.R. Brink, and E.C. Beyer. Gap Junction channels formed by co-expressed Cx40 and Cx43. Amer. J. Physiol. 281:H1675-H1688
83) 2001 Beyer, E.C., J. Gemel, V.M. Berthoud, A. Martinez, V. Valiunas and P.R. Brink. 2002 Heteromeric mixing of connexins: compatibility of partners and functional consequences. Cell Comm. and Adhesion. 8(4-6):199-204.
84) 2002 Matic M, Evans WH, Brink PR, Simon M. Epidermal stem cells do not communicate through

gap junctions. J. Invest. Derm. 118:110-116

85) 2002 Paranyuk, Y., Claros, N., Birzgalis, A., Moore, L.C., Brink, P.R. and Walcott, B. Lacrimal gland

fluid secretion and lymphocytic infiltration in the NZB/W mouse model of Sjögren’s syndrome.

Curr Eye Res 23 199-205

86) 2002 Sundermeier, T., Matthews, G., Brink, P.R. and Walcott, B. Calcium dependence of exocytosis

in lacrimal gland acinar cells. Amer. J. Physiol. 282: C360-C365

87) 2002 Walcott, B., Moore, L.C., Birzgalis, A., Claros, N., Valiunas, V., Ott, T., Willecke, C. and P.R. Brink.

The role of gap junctions in fluid secretion of lacrimal glands. Amer. J. Physiol. 282: C501-C507

88) 2002 Valiunas, V., E.C. Beyer and P.R. Brink. Gap junction channels show a quantitative difference in selectivity. Circ. Res. Jul 26;91(2):104-11.
89) 2002 Saltman, A.E., T.O. Aksehirili, V. Valiunas, G. Gaudette, N. Matsuyama, P. Brink, I. Krukenkamp.

Gap junction uncoupling protects the heart against ischemia. J. Thoracic and Cardiovas. Surgery.

124: 371-376
90) 2002 Hong, L., S. Brodsky, S. Kumari, V. Valiunas, P.R. Brink, J. Kaide, A. Nasjletti, M. Goligorsky.

Paradoxical overexpression and translocation of Cx43 in homocysteine-treated endothelial cells. Amer. J. Phyisol. 282, H2124-H2133

91) 2002 Brink, P.R. Are gap junction channels a therapeutic target and if so what properties are best exploited. Current Drug Targets 3:417-25
92) 2002 Walcott B, Moore L, Birzgalis A, Claros N, Brink PR. A model of fluid secretion by the acinar cells of the mouse lacrimal gland. Adv Exp Med Biol. 506:191-197.

93) 2002 Brink PR, Valiunas V, Moore L, Birzgalis A, Walcott B. The role of gap junctions in lacrimal acinar cells: the formation of tears. Adv Exp Med Biol. 506:109-113

94) 2002 Walcott, B., G. Matthews, P.R. Brink Differences in stimulus induced calcium increases in lacrimal gland acinar cells from normal and NZB/NZW F1 female mice. Current Eye Research 25: 253-260.

95) 2003 Martinez-Wittingham, F.J., C. Sellito, L. Li, X. Gong, P.R. Brink, R.T. Mathias, and T.W. White. Dominant cataracts result from incongruous mixing of wild-type lens connexins. J.Cell Biol. 161:

96) 2004 Plotnikov,A.N., E.A. Sosunov, J. Qu, I. Shlapakova, E.P. Anykhovsky, L.Liu, M.J. Janse, P.R. Brink, I.S. Cohen, R.B. Robinson, P. Danilo, and M.R. Rosen. A biological pacemaker implanted in thecanine left bundle branch provides ventricular escape rhythms have physiologically acceptable rates. Circulation 109:506-512
97) 2004 Goldberg, G., V. Valiunas, P.R. and Brink Selectivity Permeability of gap junction channels Biochem, Biophysica Acta. 662:96-101
98) 2004 Gemel, J., V. Valiunas, P. R. Brink, and E. C. Beyer Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells J.Cell Sci. 117:24690-2480
99) 2004 Virginijus Valiunas, Sergey Doronin, Laima Valiuniene, Irina Potapova, Joan Zuckerman, Benjamin Walcott, Richard B. Robinson, Michael R. Rosen, Peter R. Brink and Ira S.Cohen. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. Journal of Physiology: 555:617-626
100) 2004 Potapova I, Plotnikov A, Lu Z, Danilo P, Valiunas V, Qu J, Doronin S, Zuckerman J, Shlapakova I, Gao J, Pan Z, Herron A, Robinson RB, Brink PR Rosen M, and Cohen IS. Human Mesenchymal Stem Cells as a Gene Delivery System to fabricate a Biological Pacemaker Circulation Res :94:952-959.
101) 2004 Mese, G., E Londin, R. Mui, P.R. Brink, T.W. White Altered gating properties fo functional Cx26 mutants associated with recessive non-syndromic hearing loss. Human Genetics: 115:191-199
102) 2004 Valiunas V, R. Mui , E. McLachlan , G. Valdimarsson , P.R. Brink, T.W.White Biophysical characterization of Zebrafish Connexin35 hemichannels. Am. J. Physiol. (in press)

103) 2004 Rosen, M., P.R. Brink, I. Cohen, R. Robinson,. Cardiac Pacemakers for the New Millennium. Hellenic J. Cardiology 45:205-207.

104) 2004 Rosen, M.R., P.R. Brink, I. Cohen, and R. Robinson. Genes, stem cells and biological pacemakers Cardiovascular Res. 64:12-23

105) 2004 White, T.W., H. Wang, R. Mui, J. Letteral, and P.R. Brink Cloning and functional exprerssion of invertebrate connexins from Halocynthia pyriformis. FEBS Letters (in press)

Text articles:

1) 1979 Dewey, M. M., R. J. G. Levine, D. Colflesh, B. Walcott, L. Brann, E. A. Baldwin and P. R. Brink. Structural changes in thick filaments during sacromere shortening in Limulus straited muscle. In: Cross-Bridge Mechanism in Muscle Contraction, eds. Haruo Sugi and Gerald H. Pollack. Univ. of Tokyo Press, pp. 3-22.

2) 1981 Panessa, B. J., M. M. Dewey, P. R. Brink, B. Gaylinn, R. A. McCorkle, G. Coleman and J. B. Warren. High resolution x-ray contact microscopy of hydrated muscle filaments. In: 39th Ann. Proc. Electron Microscopy Soc. Amer., ed. G. W. Bailey, pp. 512-513.
3) 1981 Brink, P. R. and M. M. Dewey. Diffusion and mobility of substances inside cells. In: Techniques in the Life Sciences, ed. P. F. Baker. Elsevier/North Biomedical Press, pp. P104/1-17.
4) 1982 Dewey, M. M., D. Colflesh, P. R. Brink, S. Fan, B. Gaylinn and N. Gural. Structural, functional and chemical changes in the contractile apparatus of Limulus striated muscle as a function of sarcomere shortening and tension development. In: Basic Biology of Muscles: A Comparative Approach, eds. B. Twarog, R. J. C. Levine and M. M. Dewey. Society of General Physiologists Series, Vol. 37, pp. 53-72. Raven Press, NY.
5) 1983 Brink, P. R. and M. M. Dewey. Change in fixed-charge in the thick filament lattice of Limulus striated muscle with sarcomere shortening. In: Contractile Mechanisms in Muscle, eds. G. Pollack and H. Sugi, Raven Press.
6) 1983 Dewey, M. M., P. R. Brink, D. Colflesh, B. Gaylinn, S. Fan and F. Anapol. Limulus striated muscle provides an unusual model for muscle contraction. In: Contractile Mechanisms in Muscle, eds. G. Pollack and M. Sugi, Raven Press.
7) 1985 Brink, P. R. Solvent effects on Junctional Permeability. Cold Spring Harbor Symposium on Gap Junctions. In: Gap Junctions, ed. M. V. L. Bennett and D. C. Spray.
8) 1987 Jaslove, S. W. and P. R. Brink. The role of the gap junction in the nervous system. Intercellular Communication, Edited by W. C. DeMello. Plenum Press.
9) 1988 Brink, P. R., S. W. Jaslove, R. T. Mathias, and G. J. Baldo. The Effects of Electrical Field on Gap Junctional Membrane Currents. In: Intercellular Conference on Gap Junctions. Ed: E. Hertzberg and R. Johnson, A. R. Liss, pp. 321-334.
10) 1989 Jaslove, S. W. and P. R. Brink. Gap Junctions: Their Role in the Propagation of Action Potentials. Edited by N. Sperelakis and W.Cole CRC Press, Vol 1.
11) 1990 Brink, P. R. Patch Clamp Studies of Gap Junctions. In: Bio-physics of Gap Junction Channels. Edited by C. Peracchia CRC Press.
12) 1992 Veenstra R., and P.R. Brink. Patch Clamp methods applied to gap channels.In: Cell-cell Interactions A practical approach. Edited by B.R. Stevenson, W.J. Gallin and D.L. Paul. IRL Press at Oxford University Press.
13) 1993 Ramanan. S.V., K. Manivannan, R.T. Mathias and P.R. Brink. Heter-ogeneous channel gating in gap junctions. In: Progess in Cell Research volume 3; Gap Junctions eds. J.A Hall, G.A. Zampighi and R.M. Davis. Elsevier Press.
14) 1995 Brink. P.R., F.S. Fan, E. Grine, S.V. Ramanan, V. Mesimeris, and R. Cameron. Patch clamp of gap junction containing membranes in guinea-pig ventricular myocytes. In: Gap Junctions editor: Kanno Progress in Cell Research 4:207-210.
15) 1995 Veenstra, R.D., H.-Z. Wang, E.C. Beyer, S.V. Ramanan and P.R. Brink. Selective dye and ionic permeability of gap junction channels formed by connexin37 and connexin45. In: Gap Junctions editor: Kanno Progress in Cell Research 4:409-412
16) 1995 Christ, G.J., P.R.Brink, B. Joseph-Davis and D.C. Spray. Presence and physiologcial significance of gap junctions in vascular smooth muscle . In: Gap Junctions editor: Kanno Progress in Cell Research 4: 211-215.
17) 1995 Donahue, H.J., P.R. Brink, K.J. McLeod, E.L. Hertzberg and C.T. Rubin. Age-induced attenuation of hormonally regulated intercellular communication in bone cell networks. In: Gap Junctions editor: Kanno Progress in Cell Research 4: 349-352.
18) 1998 Beyer, E.C., K. Seul, K. Banach, D. Larson and P.R. Brink Heteromeric Connexon Formation: Analysis Using Transfected cells. In Gap Junctions edited by R. Werner. IOS Press p.91-95
19) 1998 Banach, K, S.V. Ramanan and P.R.Brink Homotypic hCx37 and rCx43 and their heterotypic form. In Gap Junctions edited by R. Werner. IOS Press p. 76-80
20) 2000 Ovadia, M, and P.R. Brink Channels, Ischemia and Stunning: Cellular Electrophysiology and Intercellular Communication. Chapter 8 In: Myocardial Viability edited by V Dilsizian Futura Publishing, Armonk, N,.Y.
21) 2000 Brink, P.R. and L. Barr. The role of gap junctions in smooth muscle cells. edited by L.Barr JAI Press Greewich Ct.
22) 2000 Brink P.R., V. Valiunas and G.J. Christ Homotypic, Heterotypic and Heteromeric gap junction channels In Curr. Top. Memb. 49:43-60. editor: C. Perrachia
23) 2001 Brink, P.R., E.C. Beyer and G. Christ What do gap junctions do anyway? Edited by P.M. Vanhoutte. Harwood Academic publishers.

Informational publications:

1992 Ramanan, S.V., P.R.Brink and R.T. Mathias. Analysis of Multichannel records

In Axobits 11 Axon Instruments Inc.Foster City Ca.
Letters to the editor:

1995 Christ ,G., A. Melman and P.R. Brink Re: Single potential analysis of carvernous electrical activity in spinal cord injury patients. J. Urology by Stief etal. J. Urology 151:367-372


1978 "Junctional Membrane Physiology," Dept. of Biology, Boston Univ.(May)

1978 "Nexus Morphology and Physiology," Boston Univ. Extension, Woods Hole (June)
1980 "Effects of Deuterium Oxide on Nexus Permeability," Dept. of Pharmacology, Columbia University (October)
1980 "Nexal Membrane Permeability," Dept. of Physiology, Univ. of Illinois - Urbana (November)
1981 "Is There an Aqueous Channel in the Nexus?", Dept. of Physiology, Yale Univ. (June)
1982 "Deuterium Oxide, its Effects on Junctional Membrane Conductance," Dept. of Neuroscience, Albert Einstein College of Medicine (June)
1983 "I-V Relationship of the Earthworm Septa Under Voltage Clamp," Dept. of Anatomy, Medical College of Pennsylvania - Philadelphia (January)
1983 "Voltage Independence of Junctional Membranes," Dept. of Physiology and Biophysics, S.U.N.Y. at Stony Brook (January)
1984 "The Nature of the Intercellular Pathway," Dept. of Physiology, Chicago Medical School (May)
1984 "Solvent Effects on Junctional Membrane Channels," Cold Spring Harbor, New York (October)
1984 "Cell Water, its Solvent Properties," Johnson & Johnson (October)
1985 "The Permeability and Conductance of Junctional Membranes, Diffusion and Other Processes," Dept. of Zoology, Univ. of Western Ontario, Canada (March)
1985 "The Cytosol as a Determinant of Solute Diffusion," BCD, S.U.N.Y. at Stony Brook (March)
1985 "The Role of the Cytosol in the Regulation of Solute Diffusion Within Cells and Through Intercellular Channels," European Society of Molecular Biology, Workshop on Gap Junctions at Rosc-off, France (June)
1986 "Electrophysiological Studies of Gap Junctions," Dept. of Anatomy, New York Medical College (September)
1987 "Characteristics of Gap Junctions Under Voltage Clamp." at Asilomar Conference on Gap Junctions (June).
1988 "Patch Recordings from a Gap Junction Containing Membrane." Dept. of Physiology & Biophysics, S.U.N.Y. at Stony Brook (April).
1988 "Patch Clamp Recordings of Gap Junctions." Dept. of Physiology. Univ. of Illinois. (Oct.)
1989 "How Gap Junctions Work." Dept. of Cardiology, Univ. of Indiana, School of Medicine (March).
1990 "Single channel recordings from the gap junction containing membranes of the septate axons of earthworm" Dept. of Physiolo-gy, Univ. of Arizona (March).
1990 "Gap Junction Channel Activity" Dept. of Neurobiology, SUNY at Stony Brook (September).
1991 "The role of Gap Junctions in Tissues" Dept. of Anatomy, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico. (April)
1991 "Gating properties of gap junction channels" Gap Junction meeting at Aslimor (June)
1992 "Myocardial gap junctions: Direct patch methods" Dept of Pharmacology Columbia Univ. (January)
1993 "Immunoglobulin secretion from human and avian plasma cells" Department of Physiology Univ. of Ill. (March)
1993 "Direct patch methods applied to mammalian intercalated discs; evidence for a putative gap junction channel" International meeting on Gap Junctions, Hiroshima Japan. (August)
1993 "Gap junction channel gating: its role in cell to cell communication". Department of Anatomy, University of Essen. Germany. (October)
1993 "Gap junction channel gating: its role in cell to cell communication". Department of Physiology, University of Bern. Switzerland.(October)
1994 "Gating in Cx43 derived gap junction channels/Can B-lymphocytes secrete non-constitutively? "Department of Physiology, East Carolina University School of Medicine, Greenville North Carolina. (March)
1994 "Comparative studies of dual whole cell and direct patch clamp of junctional membranes containing connexin43. At the Workshop on Intercellular Communication, Pushchino Russia (August)
1994 "Dynamic modulation of intercellular communication; applications to vascular biology" At the Workshop on Intercellular Communication, Pushchino Russia(August)
1994 "Calcium transport and intercellular communication in osteoblasts" Bone and Mineralized Tissue. NYU (September)
1994 "Connexin43 derived gap junction channel gating: does it have a role in second messenger intercellular diffusion in human corporal smooth muscle cells:" Univ. Arizona Department of Physiology (November)
1994 "Human Cx43 gating behavior" Univ. Ill. Department of Physiology (November)
1995 " Cx43 channel gating its role in vascular smooth muscle" Department of Physiology Penn. State (Hershey, March)
1995 " Gap Junction channel gating: physiological relevance" University of South Florida (March)
1995 "Gap junction channel gating and permselectivity" Symposium on Gap Junctions at the Experimental Biology meetings in Atlanta (April)
1996 "Gating and permselective characteristics of gap junction channels" Keystone Symposia (March)
1996 "Connexin37 and Connexin43: do they form heteromeric channels?" John B. Pierce Laboratory Seminar Series, Yale University. (August).
1997 "Underwater treks in the Caribbean and south pacific: a photo essay. St. James Audobon Society (Oct)
1998 "Gap junction channel forms: homotypic, heterotypic and heteromeric. Department of Neurobiology and Behavior SUNY at Stony Brook. January
1998 "Structure-Function relationships for gap junctions in the vasculature" Symposium on "signalling mechanisms in Vascular smooth muscle. Sandbjerg Denmark, (May)
1998 " The role of gap junctions in coordinated tissue function: permselectivity and gating". International meeting on Gap Junctions in Rio de Janiro. Brazil. (June)
1998 " Gap junction channels: homotypics, heterotypics and mutants". Department of Pharmacology and Physiology, Univ. of Rochester. (Oct).
2000 "What do gap junctions do anyway?" Meeting on Endothelial hyperpolarizing factor. In Paris France (June)
2000 " Is heteromerism functionally significant in gap junction channel function?" University of Chicago Departments of Pediatrics and Physiology and Biophysics. (July)
2000 “ Electrophysiology and contraction properties of saphenous and varicous vessels. Meeting on venous vessels, Lisbon Portugal. (September)
2001 “Properties of heteromeric gap junction channels: Is there a physiological role?”

University of Pennsylvania Medical Center Institute for Environmental Medicine

A Center for Lung Biology and Baromedicine (Apirl)

2001 Satellite meeting on microcirculation held in Australia. Symposium topic: Cell-to-Cell Coupling in Resistance Networks “Biophysics of gap junction channels between vascular cells" (August)

2002 “How might gap junctions contribute to differential smooth muscle cell function?”

At: Smooth Muscle Research Priorities (American Urological Association) Baltimore MD.

2002 Soc. Basic Urological Research at Tucson Az. “Gap Junctions their role in disease and as targets for therapeutics” (December)
2003 “Gap junction channels: participants in disease and their role as a therapeutic tool” Drexel University Medical Center, (Feb)
2003 “Gap junction channels: participants in disease and their role as a therapeutic tool” University of Tulsa, Tulsa OK (March)
2003 “Gap junction channels: participants in disease and their role as a therapeutic tool” University of Virginia at Charlottesville, (March)
2003 “Mesenchymal stem cells as pacemakers and the role of gap junction channels”

University of Texas Medical Branch at Galveston, (September)

2003 “Unique features in the evolution of cell to cell communication” New Mexico State University

Lecture in Biol 381(Animal Physiology) to biology majors in the department of Biology (Nov)

2003 “Mesenchymal stem cells as pacemakers and the role of gap junction channels” New Mexico State Univeristy (seminar to the department of Biology (Nov)
2004 “Mesenchymal stem cells as pacemakers and the role of gap junction channels” University of Alabama Birmingham. (March)
2004 “Stem cells: a tool for targeted cellular delivery of genes” University of Chicago Chicago Ill. Department of Pediatrics (Oct 4th).
2004 “Gap junction channel permeability: From spheres to rods”

Columbia University, NY, NY, Department of Pharmacology and the Institute for Molecular Therapeutics, (Oct 25th).

Scheduled talks:
“Mesenchymal stems cells as a cellular delivery system utilizing gap junction mediated communication: from cardiac pacemaker to gene silencing”.

On November 4th at the University of Utah, Salt Lake City, Utah, the Nora Eccles Harrison Cardiovascular Research and Training Institute.

“Mesenchymal stems cells as a cellular delivery system utilizing gap junction mediated communication: from cardiac pacemaker to gene silencing”. On December 13th at Wake Forest University.

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